[长期COVID - 神经疾病还是体型疾病?]
Dalma Tényi1, Tamás Tényi2, József Janszky3
1Pécsi Tudományegyetem KK, Neurológiai Klinika, Pécs.
Ideggyogyaszati szemle
|December 5, 2024
概括
长期COVID的确切原因尚不清楚,研究正在探索神经,全身和体形疾病理论. 识别病理机制是有效的长期COVID治疗的关键.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 后COVID状态 (长期COVID) 被定义为在SARS-CoV-2感染后持续症状,持续超过两个月.
- 常见的症状包括疲劳,疼痛,炼后的不适以及认知障碍 ("大脑雾").
- 长期COVID的潜在病理机制是正在进行的研究的一个关键领域.
研究的目的:
- 对长期COVID的病理机制进行文献审查.
- 综合当前关于SARS-CoV-2感染后持续症状原因的理论.
主要方法:
- 进行了对原始和评论文章的全面审查.
- 文献搜索包括2019年1月至2024年6月的匈牙利语和英语出版物.
- 搜索的数据库是PubMed和谷歌学者.
主要成果:
- 三种主要理论解释了长期的COVID病理机制:明显的神经疾病,带有神经症状的全身疾病或体形疾病.
- 神经学理论涉及病毒性神经侵袭,亡和脱髓化.
- 系统理论指出长时间的细胞因子释放和潜伏的病毒重新激活.
- 索马托形式理论表明,促炎性细胞因子网络的激活导致中枢神经系统敏感化.
- 慢性疲劳综合征,海湾战争综合征,慢性莱姆病和体征性症状障碍的严重重叠.
结论:
- 长期COVID的确切病理机制,以非特异性症状为特征,目前尚不清楚.
- 没有特定的,可复制的长期COVID生物标志物已被确定.
- 阐明病因学对于开发有效的治疗策略至关重要.
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