在儿童甲状腺切除术后影响甲状腺功能低下症的因素
Liu Yuwei1, Long Ting1, Pang Wei1
1Department of Otolaryngology, Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health (NCCH), Beijing, China.
Ear, nose, & throat journal
|December 5, 2024
概括
在甲状腺癌手术后儿童的甲状腺功能低下 (HP) 恢复通常在六个月内完成. 第一天甲状腺上腺激素 (PTH) 水平较低和淋巴结转移是延迟HP恢复的关键风险因素.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 手术瘤学手术瘤学
- 内分泌学 在内分泌学.
背景情况:
- 甲状腺功能低下症 (HP) 是完全甲状腺切除术后的常见并发症.
- 甲状腺癌是小儿科患者全甲状腺切除术的首要症状.
研究的目的:
- 为了研究癌症的甲状腺切除术后儿童的HP恢复模式.
- 为了确定影响儿童全甲状腺切除术后HP恢复的因素.
主要方法:
- 对121名为甲状腺癌进行全甲状腺切除术的儿科患者 (2016-2020年) 的回顾性分析.
- 评估临床数据,瘤特征,手术细节和淋巴结状况.
- 长期跟踪 (>1年) 记录副甲状腺激素 (PTH) 恢复时间表.
- 多变量回归分析以确定HP恢复的独立风险因素.
主要成果:
- HP发生在28.1%的患者 (34/121),平均年龄为10.34岁.
- 大多数患者 (73.5%) 在六个月内恢复了HP;5.9%在一年后恢复,5.9%在两年后仍然没有恢复.
- 在术后第一天的低PTH水平 (≤1) 和双边中央淋巴结转移是HP恢复的重要风险因素.
结论:
- 双边中央淋巴结转移和初始低PTH水平是影响HP恢复的独立风险因素.
- HP 恢复可能会发生在六个月以后,因此需要仔细考虑诊断永久的 HP.
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