常见药物对吸烟者的长度胸肌区域的影响
Toru Shirahata1,2, Nicholas A Enzer1,3, Victor Castro4
1Applied Chest Imaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States.
Chronic obstructive pulmonary diseases (Miami, Fla.)
|December 5, 2024
概括
长期使用他类药物可能会减少吸烟者的肌肉消耗,而使用阿司匹林可能会增加肌肉消耗. 需要进一步的研究来证实这些关于骨肌肉变化的发现.
科学领域:
- 肺部病理学 肺部病理学
- 老年学是一门学科.
- 药理学 药理学是指药理学的学科.
背景情况:
- 香烟烟雾是已知的导致骨肌肉消耗的原因之一.
- 虽然运动和营养是确定的治疗方法,但药物对纵向肌肉损失的影响仍然不清楚.
- 这项研究侧重于常见药物对吸烟者的骨肌肉变化的影响.
研究的目的:
- 为了研究常见药物的长期影响纵向骨肌肉变化.
- 为了确定特定药物是否影响胸部肌肉面积 (PMA) 和密度 (PMD) 在吸烟者中随着时间的推移而变化.
- 评估目前和前吸烟者的药物使用和肌肉消耗之间的关联.
主要方法:
- 使用定量计算机断层扫描成像来测量五年内胸肌面积 (delta-PMA) 和密度 (delta-PMD) 的变化.
- 分析了COPD遗传流行病学 (COPDGene®) 研究中的4191名参与者的数据.
- 用回归和倾向分数匹配 (PSM) 分析来评估药物对肌肉变化的影响.
主要成果:
- 在整体人口中,胸肌面积 (delta-PMA) 在5年内平均下降2.23厘米2.
- 立方体使用与较少的PMA损失有关,而阿司匹林使用与较大的PMA损失有关.
- 经PSM调整的分析显示,他类药物的使用减弱了PMA损失 (中位数;-1.5对-2.5厘米2,p=0.017),而阿司匹林的使用增加了PMA损失 (中位数;-2.5对-1.9厘米2,p=0.040).
结论:
- 静止剂的使用与目前和前吸烟者的胸部肌肉损耗减少有关.
- 阿司匹林使用似乎与这种人群的肌肉损失增加有关.
- 需要进一步的研究来验证这些发现,并了解潜在的机制.
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