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Updated: Jun 5, 2025

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
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A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors

Published on: December 7, 2014

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异常表达的线粒体脂类激酶,AGK,激活JAK2-基因组H3轴和BCR信号:一种机制研究,涉及到CLL治疗

Murali K Mamidi1, Sutapa Sinha2, Mariana T Mendez1

  • 1Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.

Clinical cancer research : an official journal of the American Association for Cancer Research
|December 5, 2024
PubMed
概括

异常表达的乙糖醇激酶 (AGK) 在慢性淋巴细胞白血病 (CLL) 细胞中激活Janus激酶2 (JAK2),推动细胞存活. 用BCR或BCL2抑制剂向JAK2显示出对CLL治疗的希望.

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