从诊断到手术的延迟对子宫内膜癌的影响
Dimitrios Zouzoulas1, Dimitrios Tsolakidis2, Tilemachos Karalis2
11st Department of Obstetrics - Gynecology, Aristotle University of Thessaloniki, "Papageorgiou" Hospital, Thessaloniki, Greece. dzouzoulas@hotmail.gr.
Archives of gynecology and obstetrics
|December 5, 2024
概括
延迟子宫内膜癌手术超过8周会增加辅助盆腔辐射和复发率,但不会影响整体死亡率. 由于副作用增加,这种延迟会对患者的生活质量产生负面影响.
科学领域:
- 妇科瘤学 妇科瘤学
- 手术瘤学手术瘤学
- 辐射瘤学 辐射瘤学
背景情况:
- 长期的瘤等待列表导致妇科癌症手术的延迟.
- 子宫内膜癌 (EC) 通常具有有利的预后,使其易受手术延迟的影响.
研究的目的:
- 评估延迟子宫内膜癌手术对瘤结果的影响.
- 评估手术延迟与辅助治疗的需要以及生存率之间的关系.
主要方法:
- 在2012-2019年期间接受治疗的259名子宫内膜癌患者的回顾性分析.
- 手术延迟定义为活检诊断和手术之间的时间,截止时间为8周.
- 主要结局包括辅助治疗需求和生存率 (无疾病和总体).
主要成果:
- 延迟超过8周的患者 (B组) 与在8周内手术的患者 (A组) 相比,接受盆腔辐射的可能性更高.
- 在无病生存期 (p=0.0312),观察到具有统计学意义的差异,有利于早期手术.
- 两组之间没有发现总体存活时间的显著差异.
结论:
- 延迟子宫内膜癌手术超过8周与增加对辅助盆腔辐射的需要有关.
- 迟到的手术加剧了疾病复发率,由于副作用增加,可能会影响生活质量.
- 虽然整体死亡率没有受到延迟的显著影响,但无病生存率和治疗强度受到负面影响.
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