肥胖相关的脏疾病在腹手术候选人中
Pedro Reis Pereira1,2,3, Manuela Almeida4,5,6, Patrícia Braga5,6
1Department of Nephrology, Unidade Local de Saúde de Santo António, (ULS Santo António), Porto, Portugal. pedroreisper@gmail.com.
Obesity surgery
|December 5, 2024
概括
肥胖与功能障碍有关,患者表现出较高的肌素清除率和蛋白尿. 对身体表面积的调整可能会低估腹部手术候选人的过.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 腹部外科 腹部外科
- 肥胖医学 肥胖医学
背景情况:
- 肥胖会对脏健康产生负面影响,但在减肥手术候选人中,脏功能障碍的特定标志物尚未确定.
- 了解这些标志物对于评估手术风险和患者结果至关重要.
研究的目的:
- 在接受减肥手术的肥胖患者中表征功能障碍生物标志物.
- 为了比较腹手术候选人和活着的脏捐赠者之间的功能标志物.
主要方法:
- 对400名参与者进行了倾向性得分匹配分析 (200名减肥手术候选人和200名潜在的活体脏捐赠者).
- 分析了24小时尿液收集的蛋白尿和肌素清除.
主要成果:
- 患有肥胖症 (PWO) 的患者表现出比潜在的活体脏捐赠者 (PLKD) (133.99 ± 39.06 mL/min,p=0.03) 更高的肌素清除率 (143.35 ± 45.50 mL/min).
- 在PWO中,BSA校正的肌素清除低估了过.
- 蛋白尿在PWO (139.82 ± 353.258毫克/天) 与PLKD (136.35 ± 62.24毫克/天,p<0.0001) 相比显著更高.
- 肌素清除在PWO中与蛋白尿有很强的相关性,但在PLKD中相对较小.
结论:
- 在肥胖患者中,过和不成比例的蛋白尿是常见的.
- 为BSA调整肌素清除率可能会低估腹手术候选人的过,因此应避免.
- 这些发现凸显了在这个人群中需要仔细评估功能.
相关概念视频
01:21External Anatomy of the Kidney
768
The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
768
01:24Obesity
374
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
374