检查per-和多醇基物质与乳腺,结直肠,前列腺和卵巢癌之间的关系:一个元分析
Ahmad Habibian Sezavar1, Nima Rastegar-Pouyani1, Nader Rahimi Kakavandi2
1Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Critical reviews in toxicology
|December 5, 2024
概括
这次元分析没有发现高氧化物和多氧化物 (PFAS) 暴露与常见癌症风险之间的联系. 然而,增加的 perfluorononanoic 酸 (PFNA) 和 perfluorooctanoic 酸 (PFOA) 水平显示出对乳腺癌的潜在保护作用.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 流行病学 流行病学
背景情况:
- 和多醇基物质 (PFAS) 是广泛使用的合成化学物质,具有潜在的内分泌干扰特性.
- 有关PFAS暴露与癌症风险增加之间的关联存在担忧.
研究的目的:
- 进行一项元分析,评估各种PFAS暴露与患乳腺癌,前列腺癌,结直肠癌和卵巢癌的风险之间的剂量反应关系.
- 调查特定的PFAS化合物与癌症发病率之间的潜在相关性.
主要方法:
- 通过2022年5月对主要数据库进行系统的文献搜索,确定了13项观察性研究.
- 随机效应模型被用来计算最高与最低暴露类别的概率比率 (ORs).
- 对一组研究进行了线性和非线性剂量反应分析.
主要成果:
- 在高 PFAS 暴露和乳腺,卵巢,前列腺或结直肠癌的发病率之间没有发现实质性相关性.
- 线性剂量反应分析表明,随着 perfluorononanoic 酸 (PFNA) 和 perfluorooctanoic 酸 (PFOA) 的水平增加,乳腺癌风险显著降低.
- 非线性分析显示,随着PFAS水平的增加,乳腺癌风险没有显著变化.
结论:
- 最高与最低暴露分析不支持PFAS暴露与研究的癌症风险之间的关联.
- 线性剂量反应发现表明潜在的反向关系,表明PFNA和PFOA对乳腺癌的可能保护作用.
- 建议进行进一步的研究,以探索这些潜在的保护作用.
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