在COVID-19大流行期间,从前线护理中治疗患有抑郁症的临床医生的psilocybin疗法:一项随机临床试验
Anthony L Back1, Timara K Freeman-Young1, Ladybird Morgan2
1Departments of Medicine and Psychiatry, University of Washington School of Medicine, Seattle.
JAMA network open
|December 5, 2024
概括
在COVID-19大流行后,psilocybin治疗显著减少了前线临床医生的抑郁症状. 这项研究表明psilocybin作为一种新的治疗方法,用于医疗保健工作者在流行后的心理困扰.
科学领域:
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
- 神经科学是一个神经科学.
背景情况:
- 由于COVID-19大流行,前线医疗保健工作者经历了显著的心理疾病,包括倦怠,抑郁症和PTSD.
- 现有的治疗方法可能无法完全解决临床医生在疫情后面临的独特和持续的心理健康挑战.
研究的目的:
- 为了研究psilocybin治疗在减轻美国临床医生抑郁症,倦怠和PTSD症状的疗效.
- 评估 псилоцибин疗法作为潜在的治疗大流行相关的心理困扰在医疗保健专业人员.
主要方法:
- 这是一项双盲随机临床试验,涉及30名医生,高级实践从业者 (APP) 和患有中度至重度抑郁症状的护士.
- 参与者在准备和整合课程的同时,接受了25毫克的 псилоцибин或100毫克的尼亚.
- 结果使用蒙哥马利-阿斯伯格抑郁评分表 (MADRS),斯坦福专业成就指数 (SPFI) 和PTSD检查表 (PCL-5) 来衡量结果.
主要成果:
- 与28天内尼雅相比,松素治疗导致抑郁症症状的统计显著减少 (MADRS得分) (平均差异:12.00,P <.001).
- 在松素组中观察到燃烧症状 (SPFI) 的更大改善趋势,尽管在统计学上不显著 (P = .05).
- 在psilocybin手臂中,PTSD症状 (PCL-5) 减少的数量较大,但这并未在统计上进行测试.
结论:
- 在COVID-19大流行期间,在前线工作的临床医生中,psilocybin疗法证明了抑郁症症状的显著和持续减少.
- 这些发现支持psilocybin疗法作为一个有前途的新治疗范式,用于医疗保健专业人员的流行后心理状况.
- 进一步的研究是有必要的,以探索psilocybin在临床医生心理健康方面的全部治疗潜力.
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