白血病抑制因子 (LIF) 受体放大了肺纤维化中的纤维细胞的致病激活

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Hung N Nguyen1,2, Yunju Jeong2,3,4, Yunhye Kim2,5

  • 1Department of Medicine, Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Boston, MA 02115.

Proceedings of the National Academy of Sciences of the United States of America
|December 5, 2024
PubMed
概括

准白血病抑制因子受体 (LIFR) 为纤维化肺部疾病提供了一种新的策略. 阻止LIFR可以降低纤维细胞激活和亲纤维细胞基因表达,同时解决多种疾病驱动因素.

关键词:
自隐性沟通 自隐性沟通纤维细胞的细胞.白血病抑制因子的抑制因子肺部纤维化 肺部纤维化接收器 OSM-LIF 的使用.

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