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Updated: Jun 5, 2025

4D Imaging of Protein Aggregation in Live Cells
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4D Imaging of Protein Aggregation in Live Cells

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通过UBE3C和NRF1-依赖的蛋白质体通路对急性蛋白质聚合物的时间控制

Kelsey L Hickey1,2, Alexandra Panov1,2, Enya Miguel Whelan1,2

  • 1Department of Cell Biology, Harvard Medical School, Boston MA 02115.

Proceedings of the National Academy of Sciences of the United States of America
|December 5, 2024
PubMed
概括

神经退行性疾病涉及蛋白质聚合物的积累. 这项研究揭示了涉及UBE3C和NRF1的蛋白酶体通路,降解了这些有毒聚合物,为蛋白质稳定提供了新的见解.

关键词:
蛋白质聚合物是一种蛋白质聚合物.蛋白质质量控制 蛋白质质量控制蛋白质营业额的变化乌比奎丁-蛋白酶体系统

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