在被诊断患有自闭症谱系障碍的女孩中,类固醇生成途径
Katarina Jansakova1, Martin Hill2, Hana Celusakova1
1Institute of Physiology, Faculty of Medicine, Comenius University in Bratislava, Bratislava, Slovak Republic.
PloS one
|December 5, 2024
概括
女孩的自闭症谱系障碍 (ASD) 显示了类固醇激素水平的改变,特别是高GABAergic和孕醇硫酸盐. 这表明ASD女性的类固醇生成途径的潜在差异.
科学领域:
- 神经内分泌学神经内分泌学
- 发育神经科学的发展神经科学.
- 生物化学 生物化学
背景情况:
- 自闭症谱系障碍 (ASD) 诊断在男孩中更为普遍,导致女孩在研究中的代表性不足.
- 类固醇生成途径对神经发育至关重要,但它们在女性ASD中的作用仍未得到充分研究.
研究的目的:
- 研究与神经类型对照对象相比,青春期前女孩患有ASD的类固醇生成途径内的类固醇激素水平的差异.
- 探索雌性ASD中类固醇代谢和酶活性的潜在变化.
主要方法:
- 在16名患有自闭症的青春期前女孩和16名年龄/性别匹配的神经类型对照的血样本中对结合性和非结合性类固醇的分析.
- 利用气相色谱-双重质谱测量用于精确的类固醇量化.
主要成果:
- 在患有自闭症的女孩中观察到高水平的GABAergic类固醇和孕醇硫酸.
- 在ASD组中发现了更高度的孕,其异构体,极性孕和硫酸安德罗斯坦.
- 在ASD女孩中,类固醇产品与前体的比率表明硫转移酶增加或降低类固醇硫酶活性,并可能降低类固醇11β-基酶活性.
结论:
- 与神经型女孩相比,患有自闭症的青春期前女孩在类固醇生成途径中表现出明显的改变.
- 研究结果表明,女性ASD的类固醇代谢,包括硫化和化,可能存在差异.
- 需要进一步跨性别和年龄组的研究来验证和概括这些发现.
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