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Updated: Jun 5, 2025

Generation of Orthotopic Pancreatic Tumors and Ex vivo Characterization of Tumor-Infiltrating T Cell Cytotoxicity
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目标条件扩散产生强大的TNFR超级家族抗剂和激动剂

Matthias Glögl1,2, Aditya Krishnakumar1,2, Robert J Ragotte1,2

  • 1Department of Biochemistry, University of Washington, Seattle, WA, USA.

Science (New York, N.Y.)
|December 5, 2024
PubMed
概括

使用随机噪声自由扩散的计算蛋白质设计成功地产生了针对瘤死因受体1 (TNFR1) 等具有挑战性的高亲和度结合剂. 这种方法可以精确控制特异性和功能,预示着蛋白质工程的新时代.

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