儿科口服抗瘤治疗药物的药物安全性 (youngAMBORA):一种混合方法的方法,以实现量身定制的护理计划
Phyllis Lensker1,2,3,4, Lisa Cuba1,2,3, Katja Gessner2,3
1Pharmacy Department, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
一个新的儿科护理计划,年轻AMBORA,是为了应对儿童口服抗瘤疗法 (OAT) 的挑战而开发的. 该计划侧重于药物教育,应用支持和副作用评估,改善年轻癌症患者的安全性和结果.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 儿科 儿科 儿科
背景情况:
- 口服抗瘤疗法 (OAT) 提供了更好的结果和方便,但提出了复杂的摄入挑战.
- 现有的OAT临床药理/药物护理计划在成年人中取得了成功 (AMBORA试验).
- 对于接受OAT的儿科患者,缺乏可比的护理计划.
研究的目的:
- 为接受OAT (youngAMBORA) 的儿科患者开发一个量身定制的药理/药物护理计划.
- 确定与儿童OAT相关的特定需求和教育需求.
- 提高儿科瘤学中药物安全性和治疗坚持度.
主要方法:
- 采用了并行的混合方法方法.
- 在儿童癌症中心使用的瘤实体和OAT的定量分析.
- 对患者,护理人员和医疗保健专业人员进行定性调查,以评估需求和挑战.
主要成果:
- 白血病和抗代谢物分别是最常见的诊断和OAT.
- 81.8%的儿科患者希望参与口服药物教育.
- 与护理人员相比,医疗保健专业人员认为"嗅觉/味觉"",拒绝摄入"和"吞问题"是更具挑战性的应用问题.
- 发现了两种新的副作用 ("皮肤干燥"",味道变化"),它们不在CTCAE图书馆中.
结论:
- 年轻的AMBORA计划将包括OAT咨询,儿童友好的申请支持和系统的副作用评估.
- 该计划将从患者和护理人员的角度解决17个相关的副作用.
- 将开发适合年龄的信息材料,以支持儿科患者和护理人员.
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