相关实验视频

Updated: Jun 5, 2025

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

在印度人口中通过下一代测序识别HLA-B*13:01:01:12

Samir Agarwal¹, Shikha Kumari¹, Nisha Jaiswal¹

¹Department of Lab Science and Molecular Medicine, Army Hospital Research and Referral, New Delhi, India.

|December 5, 2024

概括

一种新的人类白细胞抗原B (HLA-B) 变体,HLA-B*13:01:01:12,已经被确定. 这种新等位基因与已知的等位基因有单个核酸的差异,突出显示了HLA基因内的遗传多样性.

科学领域:

免疫遗传学免疫遗传学
分子生物学分子生物学

背景情况:

人类白细胞抗原 (HLA) 基因对免疫反应至关重要.
在HLA基因中的多态性可以影响免疫系统功能和疾病易感性.

研究的目的:

为了描述HLA-B基因新发现的变体.
描述小说和已知的HLA-B等位基因之间的遗传差异.

主要方法:

在DNA测序过程中,DNA测序
遗传变异的生物信息分析.

主要成果:

一个新的HLA-B等位基因被确定,被指定为HLA-B*13:01:01:12.
这种新等位基因通过单个核酸替代与HLA-B*13:01:01:01不同.

结论:

发现HLA-B*13:01:01:12扩大了已知的HLA-B.的等位基谱谱.
单个核酸的差异可以导致不同的HLA等位基因,这强调了高分辨率排版的重要性.

关键词:

HLA-B HLA-B 是一个很好的方法.印度人印度人印度人印度人下一代测序的下一代测序.一个新型的等位基因

更多相关视频

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

Published on: January 12, 2021

相关概念视频

Genome-wide Association Studies-GWAS

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...