癌症中的非编码RNA:机制性见解和治疗影响
Arjumand John1, Nuha Almulla2, Noureddine Elboughdiri3
1School of Bioengineering and Biosciences, Lovely Professional University, Jalandhar, Punjab 144411, India.
Pathology, research and practice
|December 5, 2024
概括
非编码RNAs (ncRNAs) 是生物过程和疾病的关键调节者,特别是癌症. 本综述检查了microRNAs和长非编码RNAs,强调它们在癌症发病和进展中的作用.
科学领域:
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
- 在瘤学瘤学.
背景情况:
- 非编码RNAs (ncRNAs) 越来越多地被认为是生物过程中的关键调节功能.
- 这些分子在各种疾病的发展和进展中发挥着重要作用,特别是人类恶性瘤.
- ncRNAs涉及到细胞系统内的各种调节机制.
研究的目的:
- 提供涉及基因表达调节的非编码RNA的全面审查.
- 检查微RNAs (miRNAs) 和长非编码RNAs (lncRNAs) 在癌症中的特定作用.
- 阐明ncRNAs对癌症发病和进展的贡献机制.
主要方法:
- 关于ncRNAs和癌症的科学出版物的文献综述.
- 分析不同ncRNA类型的调节功能,包括miRNA和lncRNA.
- 检查改变的ncRNA表达和癌症发展之间的关联.
主要成果:
- 微RNAs (miRNAs) 作为短非编码RNAs的功能,通过准信使RNA (mRNA) 来抑制基因表达.
- 异常的miRNA表达与肺癌,乳腺癌和前列腺癌等癌症的发病和进展有关.
- 长非编码RNAs (lncRNAs) 是更长的非编码RNAs,通过诸如染色体重塑和基因沉默等机制调节基因表达.
结论:
- ncRNAs,特别是miRNAs和lncRNAs,是基因表达的关键调节者.
- 这些ncRNA在广泛的人类癌症的发病和进展中起着重要作用.
- 了解ncRNA功能对于推进癌症研究和治疗策略至关重要.
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