接种COVID-19疫苗和大脑小血管疾病的进展-一个前性队列研究
Yiu Ming Bonaventure Ip1, Sangqi Pang2, Alan Yao2
1Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, HKSAR; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, HKSAR; Gerald Choa Neuroscience Institute, The Chinese University of Hong Kong, Hong Kong, HKSAR.
概括
COVID-19疫苗BNT162b2和CoronaVac没有增加大脑小血管疾病 (cSVD) 进展的风险. 这项研究没有发现疫苗接种和cSVD进展在社区居住的个人之间存在关联.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 由于SARS-CoV-2尖端蛋白与脑血管疾病之间的关联,人们对COVID-19疫苗的脑血管安全存在担忧.
- 大脑小血管疾病 (cSVD) 是中风和认知衰退的重要危险因素.
研究的目的:
- 调查BNT162b2和CoronaVac.疫苗接种后脑小血管疾病 (cSVD) 放射性进展的风险.
- 为了比较cSVD进展在接种疫苗和未接种疫苗的人群中的发生率.
主要方法:
- 一项基于社区的前性队列研究,涉及415名参与者.
- 在接种BNT162b2或CoronaVac疫苗之前和接种疫苗后4个月,或在未接种疫苗的对照组中,进行了脑部MRI扫描.
- 主要结果是六个标准cSVD生物标志物的复合物进展.
主要成果:
- 无论是BNT162b2还是CoronaVac疫苗接种都没有与cSVD进展的风险增加有关.
- 在415名参与者中,有109人 (26.3%) 显示cSVD生物标志物的进展.
- 在BNT162b2接受者中,更高的代理病毒中和测试与较低的cSVD进展风险相关.
结论:
- BNT162b2和CoronaVac疫苗似乎不会增加社区居民中cSVD的负担.
- 在BNT162b2接受者中观察到的病毒中和和减少cSVD进展之间的联系需要进一步调查.
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