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Romain J Duprat¹, Kristin A Linn², Theodore D Satterthwaite³

¹Center for Brain Imaging and Stimulation, University of Pennsylvania, Perelman School of Medicine, Department of Psychiatry, Philadelphia, USA; Center for the Neuromodulation of Depression and Stress, University of Pennsylvania, Perelman School of Medicine, Department of Psychiatry, Philadelphia, PA, USA; University of Pennsylvania, Department of Psychiatry, Philadelphia, PA, USA.

|December 5, 2024

概括

重复性跨磁刺激 (rTMS) 针对具有强烈积极功能连接到下前带皮层 (sgACC) 的大脑区域,可以有效调节抑郁症患者的sgACC活性.

科学领域:

神经科学是一个神经科学.
神经成像是一种神经成像.
精神病学是一个精神病学.

背景情况:

在抑郁症治疗中,重复性横磁性刺激 (rTMS) 的有效性与针对特定大脑区域的相关性.
在抑郁症患者中,静止状态功能连接 (rsFC) 和TMS引起的前环皮质 (sgACC) 反应之间的关系仍未得到充分研究.

研究的目的:

调查sgACC-皮层rsFC与sgACC中TMS诱导的唤起反应之间的关联.
为了比较健康对照和患有抑郁症的患者之间的这些关系.

主要方法:

115名参与者 (34人患有抑郁症) 接受了基线rsFC映射,以确定sgACC"热点".
单脉冲TMS与交联fMRI被用于测量sgACC中TMS引起的BOLD反应.
一般化的估计方程分析了sgACC BOLD响应和rsFC之间的联系.

主要成果:

在健康和抑郁群体中,对 sgACC 的高 rsFC 的皮层部位有效调节了 sgACC 活动.
在抑郁症患者中,在刺激部位更强的正 sgACC rsFC 与更大的 TMS 引起的 sgACC 反应相关.

结论:

基于rsFC的准提供了一种可行的方法,用于因果调节sgACC活动.
未来使用rTMS的抑郁症治疗策略应该考虑准正相关的部位,而不仅仅是反相关的部位,以调节sgACC.

关键词:

抑郁症抑郁症抑郁症功能连接性的功能连接性.在TMSMS中使用.功能磁力共振成像 (fMRI) 是一种功能共振成像.sgACCC是一个有价值的组织.

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