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Updated: Jun 5, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

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作为抑制P-葡萄糖蛋白活性的新目标,PROTAC具有吸引力的部位

Tatyana A Grigoreva1, Aleksandra Sagaidak1, Daria S Novikova1

  • 1Laboratory of Molecular Pharmacology, St. Petersburg State Institute of Technology (Technical University), St. Petersburg, 190013, Russia.

Archives of biochemistry and biophysics
|December 5, 2024
PubMed
概括

这项研究探讨了使用PROTACs来降解P-glycoprotein (P-gp),一种排泄输送物. 研究人员确定了多索摩芬是开发PROTACs抑制P-gp的有希望的分子.

关键词:
阻碍了排放的抑制作用.分子对接是分子对接.在P-糖蛋白 (MDR1) 中.这就是PROTAC.这些是Pyrazolopyrimidines.

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