对粒子粘附和粉末流动性的特征化技术进行全面审查
Leqi Lin1, Yun Zhang2, LiGe Wang3
1Department of Chemical Engineering, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China.
International journal of pharmaceutics
|December 5, 2024
概括
了解粒子凝聚力和粘附力是有效工业过程的关键. 本研究提供了测量技术指南,改善了制造中的粉末流动性和产品质量.
科学领域:
- 材料科学 材料科学 材料科学
- 化学工程是化学工程的重要组成部分.
- 制药制造业 制药制造业 制药制造业
背景情况:
- 粒子流动特性对工业过程具有重要影响,特别是在固体口服剂量的连续制造中.
- 凝聚性颗粒行为由于粘附而带来挑战,影响工艺效率和产品质量.
- 凝聚力和粘合力的准确表征在工艺设计中经常被忽视.
研究的目的:
- 为表面能量和凝聚力/粘合力测量技术提供实用指南.
- 为了强调选择适当的测量途径以准确地表征粉末的重要性.
- 提高对粒子相互作用的理解,以优化工业颗粒物过程.
主要方法:
- 对表面能量的各种测量技术的概述.
- 对粒子之间的凝聚力和粘合力表征方法的审查.
- 对不同表征实验及其方法差异进行比较分析.
主要成果:
- 确定用于评估粒子表面能量和粒子间力量的关键测量技术.
- 在表征实验中的方法差异的证明.
- 洞察粒子粘附,凝聚力和粉末流动性之间的关系.
结论:
- 了解表面能量和粒子间力量对于减轻分离和洪水等流量问题至关重要.
- 选择适当的测量技术对于准确的粉末表征至关重要.
- 这项工作为通过更好地控制粉末流动特性来优化连续制造流程提供了基础.
更多相关视频
08:42Challenges in Rheological Characterization of Highly Concentrated Suspensions — A Case Study for Screen-printing Silver Pastes
Published on: April 10, 2017
19.9K
11:51Visually Based Characterization of the Incipient Particle Motion in Regular Substrates: From Laminar to Turbulent Conditions
Published on: February 22, 2018
8.6K
相关概念视频
Capillarity in Fluid
134
Capillarity describes the movement of liquid in small spaces without external forces acting on it. The capillarity is driven by surface tension and adhesive interactions between the liquid and surrounding solid surfaces. This effect is often seen in narrow tubes, porous materials, and fine particles.
Surface tension is crucial to capillarity. It results from cohesive forces between liquid molecules at the liquid-air boundary, forming a skin that resists external forces. When the capillary tube...
Surface tension is crucial to capillarity. It results from cohesive forces between liquid molecules at the liquid-air boundary, forming a skin that resists external forces. When the capillary tube...
134
Characteristics of Fluids
3.8K
When a force is applied parallel to the top surface of a solid, it resists the applied force due to the internal frictional forces between the layers of the solid known as shearing resistance. However, when the force is removed, the shearing forces restore the original shape of the solid. Other deformation forces also cause temporary changes in shape if the forces are not beyond a threshold magnitude. Solids tend to retain their shape, making the study of their rest and motion easier. Beyond...
3.8K
Surface Tension, Capillary Action, and Viscosity
27.5K
Surface Tension
The various IMFs between identical molecules of a substance are examples of cohesive forces. The molecules within a liquid are surrounded by other molecules and are attracted equally in all directions by the cohesive forces within the liquid. However, the molecules on the surface of a liquid are attracted only by about one-half as many molecules. Because of the unbalanced molecular attractions on the surface molecules, liquids contract to form a shape that minimizes the number...
The various IMFs between identical molecules of a substance are examples of cohesive forces. The molecules within a liquid are surrounded by other molecules and are attracted equally in all directions by the cohesive forces within the liquid. However, the molecules on the surface of a liquid are attracted only by about one-half as many molecules. Because of the unbalanced molecular attractions on the surface molecules, liquids contract to form a shape that minimizes the number...
27.5K
Surface Tension of Fluid
231
Surface tension is a fundamental property of fluids, occurring at the boundary between a liquid and a gas or between two immiscible liquids. This phenomenon arises from the cohesive forces between molecules at the fluid's surface, creating an effect similar to a stretched elastic membrane. Inside each fluid, molecules are equally attracted in all directions by neighboring molecules, but surface molecules experience a net inward force, resulting in surface tension.
Surface tension varies...
Surface tension varies...
231
Characteristics of Dry Friction
487
Dry friction occurs when two solid surfaces slide against each other without any lubrication or fluid present. It causes resistance when pushing objects along a surface, like a gardener pushing a wheelbarrow. The force applied to move the cart causes dry friction between the wheel and the ground.
Before the wheelbarrow starts moving, the static frictional force acts tangentially to the contact surface, opposing the force that is about to induce the motion. This frictional force prevents the...
Before the wheelbarrow starts moving, the static frictional force acts tangentially to the contact surface, opposing the force that is about to induce the motion. This frictional force prevents the...
487
