急性-慢性炎症和患者的风险 对于关键病患者的脏支持
Julie-Kathryn Graham1, Molly Quillin-Mcewan, Christina Kelley
1Author Affiliations: San Diego State University, School of Nursing San Diego California (Dr Graham); and Sharp Chula Vista Medical Center, Education, Research and Professional Practice, Chula Vista, California (Dr Graham, Ms Quillin-Mcewan, and Dr Kelley).
Critical care nursing quarterly
|December 5, 2024
概括
炎症标志物C-反应蛋白 (CRP) 和D-二次体表明,高血压 (HTN) 和心力衰竭 (HF) 的住院患者的支持风险增加. 早期识别这些标记物可以帮助预防急性损伤.
科学领域:
- 临界护理医学 临界护理医学
- 腎臟病學 (nephrology) 是一種醫學.
- 心脏病学 心脏病学
背景情况:
- 在患有高血压 (HTN) 和心力衰竭 (HF) 的患者中,氨酸- ангиотензин- 氨酸系统和交感神经系统的慢性激活增加了对器官损伤的敏感性.
- 急性疾病加剧了交感神经系统的激活,增加了这些脆弱患者功能衰竭的风险.
- 早期识别损伤对于潜在地扭转器官损伤至关重要.
研究的目的:
- 检查C-反应蛋白 (CRP),D-二次体水平之间的关系,以及在成人重症监护病房的SARS-CoV-2,高血压 (HTN) 和心力衰竭 (HF) 患者中需要支持.
主要方法:
- 在重症监护病房中对189名成人SARS-CoV-2患者进行了回顾性研究.
- 分析患者病史,包括高血压 (HTN) 和先前的病.
- 评估C-反应蛋白 (CRP) 和D-二次体水平之间的相关性,以及对支持的要求.
主要成果:
- 20.6%的患者需要脏支持.
- 患有高血压 (HTN) 的病史与需要脏支持有显著的相关性 (P = 0.010).
- 较高的C-反应蛋白 (CRP) (P = 0.018) 和D-二元体 (P = 0.038) 水平显著与增加支持的需要和更严重的疾病有关.
结论:
- C-反应蛋白 (CRP) 和D-二次体是严重患有高血压 (HTN) 和心力衰竭 (HF) 的重症患者支持需求的显著预测因素.
- 这些炎症生物标志物可以提醒临床医生过度炎症和潜在的功能衰竭.
- 研究结果表明,进一步研究慢性炎症在预测急性疾病期间脏支持需求方面的作用.
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