对生物矩阵中以活动为基础检测兴奋剂物质和生长促进剂的审查:生物测试是否应该在控制计划中占有一席之地?
Liesl K Janssens1, Peter Van Eenoo2, Christophe P Stove1
1Laboratory of Toxicology, Department of Bioanalysis, Ghent University, 9000, Ghent, Belgium.
Analytica chimica acta
|December 5, 2024
概括
基于活动的生物测试为检测未知的兴奋剂物质和生长促进剂提供了一种通用方法,克服了设计药物和复杂尾酒带来的挑战. 这些验证的测试为增强的控制计划提供了可靠的结果.
科学领域:
- 分析化学 分析化学
- 生物技术是生物技术.
- 药理学 药理学是指药理学的学科.
背景情况:
- 反兴奋剂和残留物监测计划面临着新型设计药物和低水平药物尾酒的挑战.
- 测量生物活性的生物测试已经成为一种普遍的检测方法,用于检测未知的物质,无论其化学结构如何.
研究的目的:
- 审查基于活动的生物测试的应用,以检测人类和动物生物基质中的兴奋剂物质和生长促进剂.
- 在控制计划中评估生物测试的科学进展,改进和局限性.
主要方法:
- 编制和审查现有研究和基于活动的生物测试的经验.
- 讨论生物试验的改进,局限性 (例如,内源性化合物的干扰,前药物的检测) 和验证状态.
主要成果:
- 生物测试已经成功验证,证明了强大,可靠和有效的结果,用于检测兴奋剂物质和增长促进剂.
- 尽管存在局限性,但生物测试显示了将其纳入当前的控制计划的前景.
结论:
- 拟议的应用包括用于立法和研究优先级的表征化合物.
- 基于生物测试的查可以指导智能样本管理和有针对性的运动员测试.
- 生物测试指导的鉴定有助于克服使用高分辨率技术识别药物的挑战.
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