萨尔科佩尼亚,环境空气污染和认知功能在社区居住的中年和老年韩国人口中的关联:基于社区的队列研究
Jane J Lee1,2, Hae Dong Woo1, Ji Hyun Kim1
1Division of Population Health Research, Department of Precision Medicine, Korea National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju, The Republic of Korea.
BMJ open
|December 5, 2024
概括
肌肉质量丧失的萨尔科佩尼亚与老年人的认知功能下降有关. 然而,暴露于细颗粒物 (PM2.5和PM10) 并没有显示与肉症的联系,也没有影响这种认知衰退.
科学领域:
- 老年学是一门学科.
- 环境健康 环境健康
- 神经科学是一个神经科学.
背景情况:
- 萨科佩尼亚是老龄化人口日益关注的问题,可能会影响整体健康.
- 空气污染,特别是颗粒物 (PM2.5和PM10),越来越多地被认为对其系统性健康影响.
- 萨尔科佩尼亚,空气污染和认知衰退之间的相互作用需要进一步调查.
研究的目的:
- 检查萨科佩尼亚,暴露于环境PM2.5和PM10和认知功能之间的关联.
- 在韩国的一组中年和老年人中调查这些关系.
主要方法:
- 在韩国基因组和流行病学研究 (KoGES) 中进行了一项基于社区的前性队列研究.
- 参与者 (n=2274,平均年龄为70.1岁) 用韩国版本的迷你精神状态检查 (K-MMSE) 评估了萨尔科佩尼亚和认知功能.
- 对PM2.5和PM10的中长期和长期暴露进行了分析,以分析与肉症和认知功能的关系.
主要成果:
- 萨科佩尼亚与较低的认知分数 (β=-1.51,p<0.0001) 和认知功能下降的几率增加 (OR 2.34) 有关.
- 没有发现中长期或长期暴露于PM2.5或PM10和肉类的存在之间存在显著的关联.
- 暴露于空气污染并没有改变萨科佩尼亚和认知功能之间的关系.
结论:
- 萨科佩尼亚独立地与老年人的认知功能下降有关.
- 在这个队列中,中长期和长期暴露于PM2.5和PM10并没有发现与肉症有关.
- 空气污染似乎没有影响萨科佩尼亚和认知障碍之间的联系.
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