美国成年人的压力高血糖比率与非酒精性脂肪肝疾病之间的关联:基于人口的研究
Wenfeng Xi1, Wanying Liao1, Jianing Li1
1Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, China.
Nutrition, metabolism, and cardiovascular diseases : NMCD
|December 5, 2024
概括
压力高血糖比率 (SHR) 与患有糖尿病或糖尿病前期的成年人患非酒精性脂肪肝 (NAFLD) 的风险更高有关. 这一发现强调了SHR作为NAFLD发展的潜在预测因素.
科学领域:
- 代谢综合征研究 代谢综合征研究
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
背景情况:
- 压力高血糖比率 (SHR),包括血红蛋白A1c,为葡萄糖代谢提供了更深入的见解.
- 虽然SHR与心血管疾病的联系已知,但其与非酒精性脂肪肝疾病 (NAFLD) 的关联尚未被探索.
- 这项研究调查了SHR和NAFLD风险在美国成年糖尿病前期或糖尿病患者之间的关系.
研究的目的:
- 确定压力高血糖比率 (SHR) 与患非酒精性脂肪肝疾病 (NAFLD) 的风险之间的关联.
- 为了检查美国成年人被诊断患有糖尿病或糖尿病前期的队列中的这种关系.
主要方法:
- 来自2017-2020年国家健康和营养检查调查 (NHANES) 的1409名参与者的分析.
- 利用多重后勤回归,受限立方线和子组分析来评估SHR-NAFLD风险关系.
- 在完全调整的模型中对潜在的混因素进行控制.
主要成果:
- 在较高的SHR水平和增加的NAFLD风险之间观察到显著的积极关联.
- 每一个标准偏差增加的SHR与NAFLD风险增加20%相关 (OR,1.2;95%CI,1.0-1.4).
- 在各种子组中证实了SHR和NAFLD风险之间的一致线性关系.
结论:
- 压力高血糖比率 (SHR) 是糖尿病或糖尿病前期的成年人中NAFLD风险的重要预测指标.
- SHR作为一个有价值的指数,用于识别NAFLD风险较高的个体.
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