腹腔透析患者系统炎症和心血管风险总指数之间的关联
Qiqi Yan1, Guiling Liu1, Ruifeng Wang1
1Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, No.678, Furong Road, Hefei, 230601, China; Institute of Kidney Disease, Inflammation & Immunity Mediated Diseases, The Second Affiliated Hospital of Anhui Medical University, China.
Nutrition, metabolism, and cardiovascular diseases : NMCD
|December 5, 2024
概括
综合系统性炎症指数 (AISI) 与腹膜透析 (PD) 患者心血管风险较高有关. 高AISI独立预测心血管事件和死亡率在这个人群.
科学领域:
- 心血管医学 心血管医学
- 腎臟病學 (nephrology) 是一種醫學.
- 炎症生物标志物 炎症生物标志物
背景情况:
- 系统性炎症综合指数 (AISI) 是一种与各种疾病相关的新生物标志物.
- 它在腹腔透析 (PD) 患者心血管风险分层中的作用尚未得到充分证实.
研究的目的:
- 调查AISI与PD患者心血管风险之间的关联.
- 确定AISI是否可以作为该患者组心血管事件和死亡率的预测指标.
主要方法:
- 一项对316名接受PD导管插入的患者的回顾性研究.
- 分析ROC曲线,以确定最佳的AISI切线,用于预测心血管事件 (CVE).
- 卡普兰-梅尔分析和考克斯比例危险模型,以评估AISI与CVE和心血管死亡率的关联,以混因素进行调整.
主要成果:
- 一个AISI切断的213.58预测了心血管事件.
- 患有高AISI的患者的CVE和心血管死亡率的累积发病率明显较高.
- 在PD患者中,高AISI是CVE (HR:2.052) 和心血管死亡率 (HR:2.651) 的独立风险因素.
结论:
- 较高的AISI水平独立地与PD患者心血管事件和死亡率的风险增加有关.
- 在这种人群中,AISI可能是风险分层和临床决策的宝贵工具.
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