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Updated: Jun 5, 2025

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
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异常的METTL1-介导的tRNA m7G修饰改变了人类和小鼠的系统性自身免疫B细胞反应

Shuyi Wang1, Hui Han2, Yichao Qian1,3

  • 1Department of Rheumatology and Clinical Immunology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.

Nature communications
|December 5, 2024
PubMed
概括

甲基转移酶METTL1作为B细胞反应中的关键检查点. METTL1调节蛋白质翻译,影响生殖中心的形成,并控制自身免疫性疾病中的B细胞自身活性.

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相关概念视频

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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