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无标签的单细胞RNA多重复合利用遗传变异性.

Konrad Hoeft1,2, Tore Bleckwehl1, David Schumacher1,3

  • 1Department of Medicine 2 (Nephrology, Rheumatology, Clinical Immunology and Hypertension), Medical Faculty, RWTH Aachen University, Aachen, Germany.

Nature communications
|December 5, 2024
PubMed
概括

高通量单细胞RNA测序对于理解人类疾病至关重要. 一种名为SoupLadle的新方法通过利用患者遗传差异简化了多重复合,克服了大型研究的成本和复杂性障碍.

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RNA-seq03:21

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
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