在中引起的中和抗体识别了HIV-1 Envtrimer的改变形状上的V3残留物
Andrew T DeLaitsch1, Jennifer R Keeffe1, Harry B Gristick1
1Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
NPJ vaccines
|December 5, 2024
概括
研究人员确定了两种抗体,Ab1456和Ab1271,可以中和多种HIV-1菌株. 这些抗体准了改变的Envtrimer构造,为开发有效的艾滋病疫苗提供了洞察力.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 结构生物学 结构生物学
背景情况:
- 开发一种有效的HIV-1疫苗需要引起广泛中和抗体 (bNAbs).
- 目前的疫苗策略旨在诱导针对HIV-1 Env trimer上的特定表位体的抗体.
研究的目的:
- 在非人类灵长类动物中引起的两种异质中和抗体Ab1456和Ab1271的特征.
- 了解这些抗体所准的HIV-1 Env三元体的构造状况.
主要方法:
- 使用工程V3向SOSIP Env免疫原体对非人类灵长类动物进行启动.
- 通过来自不同HIV-1菌株的原生类SOSIP Envs进行增强.
- 确定与抗体Ab1456和Ab1271.1复合的Envtrimers的结构.
主要成果:
- Ab1456和Ab1271抗体向HIV-1 Env片段的V3区域.
- 在非正规的,非封闭的预注射构造中识别Envtrimers的抗体.
- Ab1456与类似于CD4结合状态的Env构造相结合,而Ab1271与改变的三元体顶部构造相结合.
结论:
- 引起的抗体可以通过向改变的Env形状来中和多种HIV-1菌株.
- 了解这些形状目标对于设计HIV-1疫苗至关重要,这些疫苗可以在封闭的预注液Envtrimers上引起对所需表位体的抗体.
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