人体血液中的微塑料颗粒及其与凝血标记物的关联
Dong-Wook Lee1, Jaehak Jung2, Seul-Ah Park2
1Department of Occupational and Environmental Medicine, Inha University Hospital, Inha University, Incheon, Republic of Korea. taesanglee89@inha.ac.kr.
Scientific reports
|December 5, 2024
概括
大多数成年人的血液中都发现了微塑料 (MP),这与使用塑料容器等生活方式因素有关. 较高的MP水平与改变的血液凝固标志物相关,表明潜在的心血管风险.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 血液学 血液学 血液学
背景情况:
- 越来越多的证据表明,微塑料 (MP) 构成健康风险.
- 血液凝固平衡的变化与MP暴露有关.
研究的目的:
- 在人体血液中对微塑料进行定量分析.
- 评估微塑料负载和血液凝结标记之间的关联.
- 探索影响微塑料暴露的生活方式因素.
主要方法:
- 对36名健康成年人的横截面研究.
- 在全血中使用福里埃变换红外光谱 (μ-FTIR) 进行微塑料分析.
- 评估生活方式因素 (例如,使用塑料食品容器).
- 对凝血 (aPTT,纤维素原) 和炎症标志物 (C-反应蛋白) 的分析.
主要成果:
- 在88.9%的参与者中检测到微塑料 (平均4.2MP/mL).
- 聚钢和聚烯是主要的塑料类型.
- 较高的MP水平与增加使用塑料食品容器相关.
- 增加的微塑料负载 (≥3 MPs/mL) 与增加的激活部分血栓形成时间 (aPTT),C反应蛋白和纤维素原相关.
结论:
- 微塑料存在于人体血液中,与生活方式选择有关.
- 在较高的MP负载下观察到血液凝结标记的显著变化.
- 研究结果强调,由于潜在的心血管风险,需要制定减少人类微塑料暴露的策略.
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