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在新诊断的多发性骨髓瘤中,单独或双重自主干细胞移植

Nora Grieb^1,2, Alexander Oeser¹, Maximilian Ferle^1,2,3

¹Innovation Center Computer Assisted Surgery (ICCAS), University of Leipzig, Leipzig, Germany.

Bone marrow transplantation

|December 5, 2024

概括

自主干细胞移植 (ASCT) 改善了多发性骨髓瘤的生存率. 双重ASCT的好处是选择的患者没有达到完全的反应,但仔细的选择至关重要,以避免更差的结果.

科学领域:

血液学血液学血液学
在瘤学瘤学.
干细胞移植干细胞移植

背景情况:

自主干细胞移植 (ASCT) 是新诊断的多发性骨髓瘤的关键治疗方法.
随着诱导和巩固策略的不断发展,需要对ASCT进行精细的患者选择.

研究的目的:

评估多发性骨髓瘤中单独与并联ASCT的不断变化的使用和结果.
为了确定患者子组,最受益于协同ASCT.

主要方法:

在1998年至2021年间,德国血造干细胞移植和细胞治疗 (DRST) 登记处的12763名患者的分析.
基于患者的特征和对治疗的反应,单个ASCT和双重ASCT之间的结果比较.

主要成果:

接受ASCT的人的中位数年龄增加,随着时间的推移,协同使用ASCT的比例下降.
整体存活率和无事件存活率在各年龄组显著改善,特别是在老年患者中.
双重ASCT在初始ASCT后未达到完全响应 (CR) 的患者中显示出益处,但与ISS III患者,功能障碍患者和获得CR的患者的较差结果有关.

结论:

ASCT仍然是一个重要的抗髓瘤疗法.
仔细选择患者进行协同ASCT至关重要,避免在ISS III患者,功能障碍患者,老年患者或在初始ASCT后获得CR的患者中使用.

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