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基于FAST,MAST和多参数MRI的头对头比较,用于诊断风险MASH的新得分

Kento Imajo^1,2,3, Yusuke Saigusa⁴, Takashi Kobayashi¹

¹Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

European radiology

|December 5, 2024

概括

新的多参数MRI (mpMRI) 评分可以识别患有代谢功能障碍相关脂肪肝炎 (MASH) 风险的患者. 结合MRE,PDFF和cT1的M-PcT策略,为处于风险的MASH提供了可靠的规则-in/out标准.

科学领域:

放射学和医学成像学医学成像学
肝病学肝病学是一种肝病学.
生物标志物生物标志物

背景情况:

代谢功能障碍相关的脂肪肝炎 (MASH) 需要准确的非侵入性诊断方法.
目前基于MASH风险分层的多参数MRI (mpMRI) 评分存在局限性.

研究的目的:

开发和验证基于mpMRI的新型评分策略,用于识别有风险的MASH.
将新策略的诊断性能与FAST和MAST等现有得分进行比较.

主要方法:

一项前性研究涉及176名怀疑有代谢功能障碍相关的脂肪性肝病 (MASLD) 的患者.
使用磁共振弹性图 (MRE) 来测量肝硬度 (LSM),质子密度脂肪分数 (PDFF) 和基于mpMRI的校正T1 (cT1).
开发了两种策略:MPcT (一个步骤的综合得分) 和M-PcT (两个步骤的顺序得分).
诊断准确性是使用5倍交叉验证与规则入选和规则排除标准来评估的.

主要成果:

与FAST和MAST相比,M-PcT策略在风险MASH的诊断性能更好.
M-PcT在接收器运行特征曲线 (AUROCs) (0.832) 下的区域比FAST (0.744) 和MAST (0.710) 高.
对于MASH风险分层,M-PcT显示了改善的正 (84.5%) 和负 (88.7%) 预测值.

结论:

通过M-PcT的两步策略,可靠地识别使用非侵入性mpMRI技术的MASH风险患者.
这种方法提供了比现有得分更好的预测性能,可能减少肝脏活检的需要.
对于MASH患者来说,M-PcT有助于预测预后和治疗决策.

关键词:

处于危险状态的MASH 很快,非常快,非常快.M-PcTT 这是一个很好的方法.这是一个巨.在MPcT中使用MPcT.

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