在患有由腹膜功能障碍引起的慢性呼吸衰竭的患者中,隔膜节奏与机械通风相比:系统性审查和元分析
Maria Lucia Arango-Cortes1,2, Luis Fernando Giraldo-Cadavid3,4, Manuel Latorre Quintana2,5
1School of Engineering, Universidad de La Sabana, Campus del Puente del Común, Chía, Cundinamarca, Colombia.
Expert review of respiratory medicine
|December 6, 2024
概括
隔膜电刺激 (DES) 可能减少脊髓损伤 (SCI) 患者的住院时间,但与机械通风相比,增加了肌缩侧面硬化症 (ALS) 患者的死亡率.
科学领域:
- 医疗技术 医疗技术 医学技术
- 呼吸系统医学 呼吸系统医学
- 神经学 神经学
背景情况:
- 隔膜电刺激 (DES) 与机械通风 (MV) 的相对有效性在改善患者的治疗结果方面尚未得到充分证实.
- 现有研究表明,关于生活质量 (QOL) 和住院时间的结果不一致.
研究的目的:
- 系统地审查和分析DES与MV的临床结果,与大人的腹膜功能障碍.
- 评估DES对死亡率,住院时间,QOL和呼吸道感染的影响.
主要方法:
- 在主要的科学数据库 (PubMed,Scopus,Google Scholar,LILACS,IEEE Xplore) 中进行了全面的搜索.
- 包括在内的是对成年人患有腹膜或的DES与MV的比较研究 (RCT和观察).
- 数据提取和偏差评估由两位作者独立进行.
主要成果:
- 纳入了9项涉及852名受试者的研究. 在脊髓损伤 (SCI) 中,DES显示出短期住院的潜力,但在死亡率和呼吸道感染方面产生了不同的结果.
- 在肌缩侧面硬化症 (ALS) 中,DES与较高的死亡率和相似的QOL相关,与MV相比.
- 在大多数SCI研究中,注意到存在重大偏差风险.
结论:
- 隔膜电刺激 (DES) 可能有助于减少SCI患者住院和呼吸道感染.
- 然而,与机械通风相比,DES与ALS患者的死亡率增加有关.
- 需要进一步进行高质量的研究,以澄清DES在治疗隔膜功能障碍中的作用.
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