生物学年龄影响磨损和牙损失在后续研究中的研究
1Dental Clinics, Department of Periodontology, University Medicine Greifswald, Greifswald, Germany.
Journal of dental research
|December 6, 2024
概括
生物学年龄 (BA) 在纵向研究中预测了消耗. 年轻的BA个体不太可能退学,健康状况更好,在10年内保留更多的牙,这影响了研究的概括性.
科学领域:
- 老年学与公共卫生
- 生物标志物和衰老研究
- 牙科流行病学 牙科流行病学
背景情况:
- 纵向研究面临来自参与者不响应和消耗的偏见.
- 消耗对基于人口的研究得出的结论的有效性产生重大影响.
- 这个问题在牙科研究中特别没有得到解决,需要进行调查.
研究的目的:
- 在一项为期10年的随访研究中,研究磨损对牙损失和死亡率的影响.
- 评估生物年龄 (BA) 在预测消耗及其对健康结果的影响中的作用.
- 了解磨损如何影响纵向牙科研究结果的概括性.
主要方法:
- 在波默兰的健康研究 (SHIP-0) 中,从10个系统生物标志物中构建了一个生物年龄 (BA) 评分.
- 根据BA相对于时间年龄 (CA) 的关系,分层3417名有牙的参与者分为三级.
- 在10年随访期间 (SHIP-2) 与BA-CA层相比,比较了基线特征,磨损倾向和牙损失.
主要成果:
- 磨损倾向是剂量依赖于BA-CA得分和社会经济因素.
- 年轻的BA参与者在放弃者中代表性不足,在随访参与者中代表性过高.
- 年轻的BA个体表现出更有利的风险概况,更好的口腔健康和更低的死亡率;他们的牙保留受了基线BA的影响.
结论:
- 在长期研究中,在BA中汇总的个体风险概况预测了对磨损的易感性.
- 磨损改变了基于BA的研究参与者组成,影响了结果对基线人群的可转移性.
- 基线BA梯度随着时间的推移而持续,突出其对健康结果和研究参与的持久影响.
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