重新利用FDA批准的COVID-19药物:通过多相in silico方法准主要蛋白酶

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A Fluorogenic Peptide Cleavage Assay to Screen for Proteolytic Activity: Applications for coronavirus spike protein activation

Published on: January 9, 2019

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Ahmed M Metwaly1, Eslam B Elkaeed2, Aisha A Alsfouk3

  • 1Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.

Antiviral therapy
|December 6, 2024
PubMed
概括

这项研究选了FDA批准的药物用于SARS-CoV-2主蛋白酶 (Mpro) 抑制. 阿塔萨那维尔显示出强大的结合和稳定的相互作用,表明其作为COVID-19治疗剂的潜力.

关键词:
阿塔萨纳维尔 (atazanavir) 是一种药物.美国食品和药物管理局批准的药物.这就是SARS-CoV-2病毒.药物重用是为了改变药物的用途.主要蛋白质酶的主要蛋白质酶分子对接的分子对接.分子动力学模拟模拟

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