训练免疫的治疗潜力对于恶性疾病的治疗潜力
Hiroyuki Takahashi1, Daibo Kojima1, Masato Watanabe1
1Department of Surgery, Fukuoka University Chikushi Hospital, Chikushino, Fukuoka, Japan.
Immunological medicine
|December 6, 2024
概括
训练免疫 (TI) 是一种先天性免疫细胞记忆的形式,在癌症治疗中表现有前途. 它增强了抗瘤反应,并可能降低瘤发展风险.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
背景情况:
- 训练免疫 (TI) 涉及先天性免疫细胞 (IIC) 的功能记忆,使得对病原体的反应更快,更非特异.
- 这种记忆是由表观遗传改变,免疫信号和代谢变化介导的.
- 虽然免疫检查点抑制剂和工程T细胞已被确立为癌症治疗方法,但TI在瘤微环境 (TME) 中的作用正在出现.
研究的目的:
- 探索训练免疫 (TI) 作为一种新的抗癌治疗策略的潜力.
- 阐明TI可以在瘤微环境 (TME) 中利用的机制.
主要方法:
- 审查关于微生物和具有瘤杀伤作用的疫苗的累积证据.
- 分析TI在瘤治疗中的拟议作用,包括细胞因子促进,细胞增强,T细胞招募,免疫抑制逆转和病原体去除.
- 基于其耐用性,考虑TI对瘤发展风险的潜在影响.
主要成果:
- 有证据表明,TI可以诱导瘤杀伤性作用,可能通过各种机制.
- TI可能促进促炎性细胞因子分泌,增强细胞化.
- TI可以通过新抗原呈现促进癌症特异性细胞毒性T细胞向TME扩张和招募.
- TI可能会在TME内逆转免疫抑制,并消除致癌性病原体.
- 持久的TI可能会降低瘤发展的风险.
结论:
- 训练免疫 (TI) 为癌症治疗提出了新的治疗愿望.
- 在TME中利用TI机制可以为抗击癌症提供一种新的方法.
- 天生的免疫细胞的功能记忆为未来的抗癌策略提供了一个有希望的途径.
更多相关视频
相关概念视频
Tumor Immunotherapy
476
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
476
Cytotoxic T Cells-mediated Immune Response
846
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
846
Cancer Vaccines
338
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
338
Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
Cell-mediated Immune Responses
67.0K
Overview
67.0K
Mitogens and the Cell Cycle
6.4K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.4K


