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Updated: Jun 5, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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在人类癌症中TP53独特的误解突变谱的表型映射

Lakshay Malhotra1,2, Alankrita Singh1, Punit Kaur1

  • 1Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India.

Journal of biomolecular structure & dynamics
|December 6, 2024
PubMed
概括

在人类癌症中,p53瘤抑制基因经常发生突变. 这项研究绘制了1,297个独特的误解突变,揭示了它们对p53蛋白功能和各种组织的发生的影响,提供了潜在的治疗点.

关键词:
灭症 (apoptosis) 是一种死亡的过程.错误的感觉突变的突变.在p53中,p53是什么?现象型 现象型 是一种现象型.瘤抑制剂是一种瘤抑制剂.

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