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Updated: Jun 5, 2025

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
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关于DENV-3甲基转移酶抑制机制的全原子视角

Xiao Liu1, Kaiwen Pang1, Hangfei Wu1

  • 1School of Mathematics, Physics and Statistics, Shanghai University of Engineering Science, Shanghai 201620, China.

The journal of physical chemistry. B
|December 6, 2024
PubMed
概括

研究人员使用氨酸扫描研究了登革热病毒3型甲基转移酶 (MTase) 抑制. 他们确定了关键的残留物和14种对抑制剂产生耐药性的突变,有助于药物开发.

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