慢性病患者的食尼亚摄入量和死亡率
Zhengxi Zhou1, Xiaotian Yao1,2,3
1Department of Urology, Ningbo Mingzhou Hospital, Zhejiang, China.
Frontiers in nutrition
|December 6, 2024
概括
较高的食尼亚摄入量与慢性病 (CKD) 患者的死亡率降低有关. 这一发现表明,氨酸可能在CKD结局中起着保护作用.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 尼亚对慢性病 (CKD) 患者的死亡风险的影响尚未得到充分证实.
- 了解这种关系对于管理CKD患者的健康结果至关重要.
研究的目的:
- 为了研究饮食中素摄入量与成年CKD患者的死亡风险之间的关联.
- 为了确定素摄入是否与所有原因和心血管疾病 (CVD) 死亡率的降低相关.
主要方法:
- 一项使用2003-2018年国家健康和营养检查调查 (NHANES) 数据的队列研究.
- 包括6110名成年CKD患者,通过24小时的饮食回忆评估尼亚摄入量.
- 分析使用加权的考克斯比例危险模型和受限制的立方线,使用来自国家死亡指数 (NDI) 的死亡率数据.
主要成果:
- 尼雅摄入量的中位数为20.89毫克/天 (IQR:15.67-27.99毫克/天).
- 在87个月的中位数随访期间,发生了1984例因各种原因死亡和714例心血管疾病死亡.
- 与较低摄入量相比,较高的尼亚摄入量 (≥22 mg/天) 与所有原因死亡率 (HR:0.71;95% CI:0.57-0.88) 和心血管疾病死亡率 (HR:0.75;95% CI:0.57-0.98) 的风险显著降低有关.
结论:
- 饮食中氨酸摄入量与慢性病患者全因和心血管死亡率的降低有显著的关联.
- 这些发现突出了充分的氨酸消费在控制CKD患者死亡风险方面的潜在保护作用.
相关概念视频
Myocarditis IV: Nursing Management
1
Myocarditis is an inflammatory condition of the myocardium requiring meticulous nursing management for optimal patient outcomes. Effective management begins with a thorough assessment of the patient's medical history, paying close attention to past infections, autoimmune disorders, travel history, and exposure to toxins or drugs. Recent viral infections and systemic diseases are particularly relevant due to their potential role in triggering myocarditis.Physical Examination and MonitoringThe...
1
Factors Affecting Renal Clearance: Renal Impairment
53
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
53
Nephrons
2.2K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
2.2K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
57
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
57
Renal Failure: Dose Adjustments
63
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
63


