植物衍生的外体样纳米纤维的工程策略:当前知识和未来前景
Yuhan Li1, Yulong Wang1, Hongrui Zhao2
1Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
International journal of nanomedicine
|December 6, 2024
概括
来自植物的外体样纳米纤维 (PELNs) 显示出治疗潜力,但需要工程来更好地准和有效. 本综述涵盖了PELN生物发生,隔离,表征和改进的生物医学应用的工程策略.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 植物科学 植物科学
背景情况:
- 植物衍生的外体样纳米纤维 (PELNs) 含有具有治疗潜力的生物活性成分.
- 它们的天然来源为生物医学应用提供了良好的生物相容性和生物可用性.
- 目前的局限性包括不充分的向和有限的治疗效果.
研究的目的:
- 提供PELN生物发生,隔离,表征和治疗功能的全面概述.
- 审查目前对PELNs工程策略的知识.
- 讨论工程PELN应用的未来方向.
主要方法:
- 关于PELN隔离 (超离心,尺寸排除染色体) 和表征的文献综述.
- 分析工程策略,包括膜杂交和表面功能化.
- 检查治疗有效载荷的封装方法.
主要成果:
- PELNs拥有各种各样的生物活性成分.
- 工程方法可以提高PELN的向性和治疗效率.
- 对于PELN的隔离,净化和表征,存在各种方法.
结论:
- 工程PELN在疾病预防和治疗方面具有显著的前景.
- 对工程策略的进一步研究将扩大其临床实用性.
- 优化PELN传递系统对于未来的生物医学应用至关重要.
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