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细胞外囊泡用于在缺血/再损伤中输送治疗剂

Weihang Zhou¹, Xinchi Jiang^1,2, Jianqing Gao^1,3,2

¹State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.

Asian journal of pharmaceutical sciences

|December 6, 2024

概括

细胞外囊泡 (EVs) 显示出通过输送治疗剂来治疗缺血/再输液 (I/R) 损伤的潜力. 工程电动汽车提高了它们在I/R处理中的有效性,解决了交付和生产中的挑战.

科学领域:

生物医学工程生物医学工程
再生医学是一种再生医学.
细胞和分子医学细胞和分子医学

背景情况:

缺血/反 (I/R) 损伤涉及由于血液流量受到限制和恢复而导致组织损伤,导致严重的健康后果.
细胞外囊泡 (EVs) 是细胞间通信的关键媒介,通过它们的载荷影响受体细胞功能.
电动汽车正在成为治疗各种疾病的有希望的治疗交付车辆,包括I / R损伤.

研究的目的:

审查I / R损伤的病理学和EVs的生物物理特征.
探索来自各种细胞来源的EVs对I/R损伤的治疗潜力.
讨论提高EV治疗疗效和克服交付挑战的战略.

主要方法:

文献综述侧重于I/R损伤机制和EV生物学.
对研究基于EV的I/R损伤疗法的临床前研究的分析.
检查电动汽车工程策略,包括表面修改和预先调节.

主要成果:

EVs作为针对I/R损伤的治疗剂的无毒,适应性强的载体.
来自干细胞,内皮细胞和血的EV在I/R环境中显示出治疗潜力.
表面修饰和内容调制是提高EV治疗功效的有效策略.

结论:

工程电动汽车为开发新型I/R伤害治疗提供了一个多功能平台.
需要进一步的研究来应对大规模电动汽车生产和针对临床应用的目标交付所面临的挑战.
基于EV的疗法在推进I/R伤害管理方面具有重大前景.

关键词:

药物输送是药物输送的过程.细胞外囊泡工程细胞外囊泡工程细胞外囊泡中的细胞外囊泡.缺血/再输液损伤缺血/再输液损伤纳米载体纳米载体是什么

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