在类风湿性关节炎患者中Helicobacter pylori的血清流行率与间歇性肺部疾病患者
Shomi Oka1,2, Takashi Higuchi1, Hiroshi Furukawa1,2
1Department of Rheumatology, NHO Tokyo National Hospital, Kiyose, Japan.
Biomarker insights
|December 6, 2024
概括
在风湿性关节炎患者中,Helicobacter pylori感染较少发生,这些患者患有间歇性肺部疾病. 这表明,H. pylori可能通过预防胃食道逆流病来保护RA中的ILD.
科学领域:
- 类风湿病学 类风湿病学
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
背景情况:
- 类风湿性关节炎 (RA) 经常与间歇性肺病 (ILD) 一起发生.
- 众所周知,Helicobacter pylori感染可以预防胃食道逆流性疾病 (GERD),这是异常性肺纤维化的一个危险因素.
- 在患有ILD的RA患者中,H. pylori的患病率仍未得到充分研究.
研究的目的:
- 研究患有类风湿性关节炎和间歇性肺部疾病的患者中H. pylori感染的流行情况.
- 为了确定H. pylori血清阳性和RA患者ILD存在之间的关联.
主要方法:
- 进行了一项病例控制观察性研究.
- 在RA患者的血清中测量了抗H. pylori抗体,使用酶相关免疫吸收试验 (ELISA).
- 在患有慢性肺病和没有慢性肺病的RA患者之间比较了患病率.
主要成果:
- 抗H.pylori抗体的阳性在患有ILD (18.0%) 和慢性肺病 (18.2%) 的RA患者中明显较低,与没有慢性肺病 (27.5%) 的患者相比.
- 具体来说,H. pylori阳性在常见的间歇性肺炎 (14.3%) 和呼吸道疾病 (18.0%) 中较低.
- 后勤回归分析表明,H. pylori抗体独立且具有保护性,与RA中的慢性肺病相关.
结论:
- 在风湿性关节炎患者中,H. pylori的血清流行率降低,这些患者还患有间歇性肺病.
- H. pylori 感染可能对 RA 患者的 ILD 发展产生保护作用,可能通过减轻 GERD.
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