尿与心脏几何和左心室功能之间的关系:强心脏研究.
Wil Lieberman-Cribbin1, Irene Martinez-Morata1, Arce Domingo-Relloso1,2
1Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, New York, USA.
JACC. Advances
|December 6, 2024
概括
饮用水中的含量升高与美国印第安人成年人的不良心脏变化有关. 这项研究强调了需要制定战略来减少暴露及其潜在的心血管风险.
科学领域:
- 环境健康 环境健康
- 心血管科学 心血管科学
- 毒理学 毒理学 毒理学
背景情况:
- 是美国饮用水中发现的非必需元素.
- 暴露于会带来潜在的心脏毒性风险.
研究的目的:
- 评估尿路度与心脏几何和功能之间的关联.
- 研究的重点是来自强心家庭研究的美国印第安人年轻人.
主要方法:
- 1,332名参与者 (糖尿病,心血管疾病,50岁以下) 在基线和随访时被评估.
- 测量了尿,心声和血压.
- 线性混合效应模型被用来分析随时间变化的变化.
主要成果:
- 高尿与左心室质量指数增加和左心房直径增加相关.
- 暴露于与较高的脉压和发生的左心室缩有关.
- 在横截面和前性分析中观察到的结果.
结论:
- 尿中的含量与心脏几何和功能有关.
- 研究结果表明,慢性暴露对心血管有潜在的长期影响.
- 减少暴露的战略是有必要的.
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