监督和家庭运动活动干预对癌症患者循环免疫细胞数量的影响
Rihacek Michal1,2,3, Wagnerova Andrea3,4, Halamkova Jana5
1Department of Hematology and Transfusion, AGEL Central Moravia Hospitals, AGEL Prostejov Hospital, Mathonova 1, 796 01, Prostejov, Czechia.
Heliyon
|December 6, 2024
概括
监控的运动计划有助于稳定接受治疗的癌症患者的免疫细胞,与控制组不同,该组的免疫细胞显著下降. 这表明运动可以对癌症患者的免疫健康有益.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 运动科学 运动科学
背景情况:
- 恶性疾病需要平衡治疗强度与患者的生活质量.
- 定期的体力活动和远程健康炼训练为癌症患者提供了显著的精神和身体健康益处.
- 运动可以帮助管理抗癌治疗的副作用,并可能增强免疫功能.
研究的目的:
- 分析监控运动计划对正在接受固体恶性瘤治疗的患者循环免疫细胞的长期影响.
- 为了比较参与监控运动计划的癌症患者和对照组之间的免疫学概况.
主要方法:
- 在捷克共和国马萨里克纪念癌症研究所的一项随机研究,涉及49名患有固体恶性瘤的参与者.
- 参与者被分为一个实验组 (SAPA) 接受监控在线炼计划和一个控制组 (CO).
- 流细胞计用于检查细胞免疫学概况,SAPA组每周进行三次在线炼.
主要成果:
- 在SAPA组中,淋巴细胞数量保持稳定,而在CO组中,淋巴细胞数量显著下降 (-23.0%).
- 与CO组相比,SAPA组在运动后的B淋巴细胞数量显著更高 (p=0.003).
- 关键免疫细胞包括Th-淋巴细胞,T-c淋巴细胞,T-玛/三角淋巴细胞和NK细胞在SAPA组保持稳定,但在CO组下降.
结论:
- 控制的体力活动,如监控的炼计划,稳定或增加癌症患者接受化疗的特定免疫细胞群.
- 这些发现强调了将运动纳入癌症治疗方案中的潜在好处,以支持免疫健康.
- 这项研究支持先前的研究表明,运动可以积极影响癌症患者的免疫细胞数量.
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