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目前的证据缺口支持在怀孕期间进行系统性细胞巨乳病毒查

Agathe Billette de Villemeur¹, Bruno Hoen^1,2, Eric Billaud³

¹Haut Conseil de Santé Publique, Paris F-75000, France.

EClinicalMedicine

|December 6, 2024

概括

由于缺乏关于预防新生儿后遗症和有效干预措施的证据,怀孕妇女对细胞巨乳病毒 (CMV) 感染的查受到争议. 目前的情况不支持在怀孕期间进行普遍的CMV查作为标准实践.

科学领域:

产科和妇科产科和妇科
传染性疾病传染性疾病
新生儿健康新生儿健康

背景情况:

怀孕期间细胞巨乳病毒 (CMV) 查的好处尚未得到充分证实.
没有任何随机试验比较了查与例行管理,以预防严重的新生儿后果.
有限的证据表明,在CMV查结果呈阳性后,有效的干预措施是有限的,治疗的窗口很窄.

研究的目的:

突出与在怀孕期间实施通用CMV查相关的挑战.
刺激讨论在CMV查成为标准实践之前解决差距.

主要方法:

这个观点讨论了当前的证据和挑战.
它综合了有关虚假阳性,成本效益和医疗保健专业人员能力的担忧.

主要成果:

普遍查可能会产生许多错误的阳性结果.
有关成本效益和医疗保健系统管理工作量增加的能力存在担忧.
没有任何治疗方法对先天性CMV感染率有显著影响.

结论:

在怀孕期间实施通用CMV查计划的条件尚未满足.
需要进一步的研究来应对诊断和治疗方面的挑战.
在标准化CMV查之前,必须填补知识和基础设施的差距.

关键词:

遗传性细胞巨型病毒感染.细胞巨乳病毒感染系统的选系统的选.瓦拉西克洛维尔是什么意思

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Cytomegalovirus Disease

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...