在败血症中可溶性ST2的诊断和预后价值
Xinghua Ye1, Jia Wang1, Le Hu1
1Emergency Medicine Clinical Research Center, Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Frontiers in medicine
|December 6, 2024
概括
溶性抑制瘤性2 (sST2) 水平在败血症患者中升高,并预测预后. sST2显示了与SOFA和APACHE II分数相似的预测能力,表现优于乳酸.
科学领域:
- 生物化学 生物化学
- 关键护理医学 关键护理医学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 败血症是一种危及生命的器官功能障碍,是由宿主对感染反应失调引起的.
- 准确的诊断和预后标记对于治疗败血症患者至关重要.
- 瘤发生性2 (sST2) 的可溶性抑制是炎症状况中的潜在生物标志物.
研究的目的:
- 评估瘤性2 (sST2) 的可溶性抑制在患有败血症的重症患者的诊断和预后价值.
- 将sST2的预测性能与已有的评分系统和生物标志物进行比较.
主要方法:
- 招募了113名危急病患者,并分为败血症 (76) 和非败血症 (37) 组.
- 使用免疫试验测量血清sST2水平;计算SOFA,qSOFA和APACHE II分数.
- 用物流回归和ROC曲线分析来评估诊断和预后因素.
主要成果:
- 与非败血症组相比,败血症组的血清sST2水平显著更高 (p <0.05).
- 非幸存者比幸存者表现出明显更高的sST2,SOFA,APACHE II分数和乳酸水平 (p <0.05).
- sST2,SOFA,APACHE II分数和乳酸是预后不佳的独立风险因素;sST2的AUC与SOFA和APACHE II相比较,但高于乳酸.
结论:
- 血液中的sST2水平在败血症中具有显著的诊断和预后价值.
- sST2显示出与SOFA和APACHE II分数相比较的败血症预后预测能力.
- sST2表现出优越的预测能力超过乳酸水平的败血症预后.
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