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支气管切除症在炎症性肠病中的流行:系统性审查和元分析
Yu Ma1, Zhihui Qiang1, Miaomiao Zhou1
1Department of Respiratory and Critical Care Medicine, Xi'an Jiaotong University Second Affiliated Hospital, Xi'an, China.
Frontiers in medicine
|December 6, 2024
概括
与炎症性肠病相关的支气管切除 (IBD-BE) 影响5%的IBD患者,但当使用高分辨率胸部CT时,这种患病率上升至12%. 需要标准化的诊断方法来理解这种肺部表现.
科学领域:
- 胃肠病学 胃肠病学
- 肺部病理学 肺部病理学
- 流行病学 流行病学
背景情况:
- 炎症性肠病 (IBD) 与各种肠外表现有关.
- 肺部干扰,特别是支气管切除,在IBD患者中越来越多地被认可.
- 了解IBD相关支气管切除症 (IBD-BE) 的发生率和危险因素对于全面的患者护理至关重要.
研究的目的:
- 系统地审查和元分析IBD相关支气管切开症 (IBD-BE) 的发生率.
- 探索与IBD-BE相关的潜在风险因素.
- 确定IBD-BE的全球患病率及其在IBD中的肺部表现.
主要方法:
- 在PubMed和EMBASE数据库的系统文献搜索.
- 对16项涉及92,191名IBD患者的研究进行了元分析.
- 提取关于研究设计,诊断方法,IBD特征和IBD-BE病例的数据.
- 根据研究类型,疾病特征和诊断方式进行子组分析.
主要成果:
- 整体IBD-BE的综合流行率为5.0% (95%CI为2.0-12.0%).
- 使用高分辨率胸部计算机断层扫描 (HRCT) 的研究报告了更高的患病率12% (95% CI 4-39%).
- 根据研究设计和样本大小,患病率差异很大,前性研究显示11%,后性研究显示1-29%.
结论:
- 支气管切除是一种常见的,可能被低估的IBD的肠外表现.
- 在使用HRCT成像诊断时,IBD-BE的患病率显著更高.
- 诊断方法的标准化对于未来研究IBD-BE的自然史和临床过程至关重要.
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