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预测和预防晚发性子宫前:一个系统的审查

Anna Baylis¹, Wei Zhou^1,2, Ellen Menkhorst^1,2

¹Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Parkville, VIC, Australia.

Frontiers in medicine

|December 6, 2024

概括

晚发性子宫前 (LOP) 是常见的,但预测和预防缺乏. 在17周之前服用低剂量阿司匹林可能有助于高风险怀孕,但需要更多的研究.

科学领域:

产科和妇科产科和妇科
孕产妇和胎儿医学孕产妇和胎儿医学
围产期健康围产期健康

背景情况:

孕前症对围产期生存构成重大全球威胁.
在怀孕34周或之后发生的晚发性子宫前 (LOP) 是主要的形式.
目前在LOP预测和预防策略中存在知识差距.

研究的目的:

系统地审查现有的关于预测和预防晚发性子宫前的文献.
确定LOP的关键风险因素和潜在干预措施.
为临床监测提供信息,并改善高风险怀孕的结果.

主要方法:

在PubMed.com上进行了系统的文献搜索.
包括专注于预测或预防人类LOP的研究,发表于2013年至2023年之间.
搜索术语包括"晚发前"",危险因素"",预测"",管理"和"预防".

主要成果:

在最终分析中包含了16篇文章.
确定的LOP风险因素包括高体重指数 (BMI),慢性高血压,高平均动脉压 (MAP),nulliparity和晚年母亲年龄.
在妊娠17周之前开始服用低剂量阿司匹林可能会降低高风险个体的LOP风险;然而,没有确定LOP的临床验证的预测模型.

结论:

阿司匹林在高风险怀孕中对LOP预防有希望,但对于低风险组或晚期怀孕需要进一步的干预.
鉴定LOP的新生物标志物至关重要,特别是通过对第二或第三个三个月的大群体的研究.
发现生物标志物可以为高风险LOP患者提供有针对性的预防措施.

关键词:

晚期发病的子宫前症.管理的管理管理的管理.预测预测预测预测预防预防预防风险因素的风险因素是什么

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