超越传统的查:揭示了在极端环境中活性菌体的抗生素潜力
Lyudmila P Trenozhnikova1, Gul B Baimakhanova1, Baiken B Baimakhanova1
1LLP Research and Production Center for Microbiology and Virology, Almaty, Republic of Kazakhstan, Kazakhstan.
Heliyon
|December 6, 2024
概括
极端的生态系统拥有生产新型抗生素的动态菌体. 这项研究选了来自哈萨克斯坦的667个分离物.
科学领域:
- 微生物学 微生物学
- 环境科学 环境科学
- 药物发现 药物发现 药物发现
背景情况:
- 极端生态系统是特殊代谢物的有希望的来源,有可能对抗多种药物耐药性.
- 传统的抗生素发现方法面临效率和范围的局限性.
- 来自极端环境的行为菌群被假设具有独特的抗生素生产能力.
研究的目的:
- 为来自极端息地的天然抗生素生产者开发一种新的查方法.
- 调查与抗生素生产有关的行为菌素的适应性特征和代谢活动.
- 在哈萨克斯坦的各种极端环境中识别潜在的新抗生素来源.
主要方法:
- 从哈萨克斯坦的160个极端息地样本中收集了667个形虫隔离物.
- 在中性,盐和条件下对MRSA,大肠杆菌,C. albicans和A. niger进行评估的抗菌和抗真菌特性.
- 进行了分子遗传分析,以确定主要的属,重点是Streptomyces和Nocardiopsis.
主要成果:
- 113个分离体显示出抗菌活性,109个显示出抗真菌活性.
- 五分之一的活性分离物只在极端条件下产生物质.
- 83.4%的分离物在中性,盐和条件下壮成长; 99.7%的分离物耐受3.5%的NaCl.
结论:
- 来自极端环境的行为菌群具有多功能性和适应性,显示出抗生素生产的潜力.
- 基于适应性特征的新型查平台可以加速发现新的天然抗生素.
- 53个有前途的菌株需要进一步研究,以开发新型抗生素.
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