对一腿骑自行车运动的同情反应预测了心力衰竭患者的运动能力,这些患者有保存的喷射分数
Mark B Badrov1,2,3, Tomoyuki Tobushi1,2,3, Catherine F Notarius1,2
1University Health Network and Sinai Health, Department of Medicine (M.B.B., T.T., C.F.N., E.K., M.N., D.Z.C., S.M., J.S.F.), University of Toronto, ON, Canada.
Circulation. Heart failure
|December 6, 2024
概括
患有心力衰竭并保持射出分数 (HFpEF) 的患者在休息和运动期间表现出较高的肌肉交感神经活动 (MSNA). 骑自行车时这种增强的同情反应与HFpEF运动能力的降低有关.
科学领域:
- 心血管生理学心血管生理学
- 神经心脏病学 神经心脏病学
- 心脏衰竭病理生理学 病理生理学
背景情况:
- 交感神经系统过度活跃和运动不耐受是心力衰竭 (HF) 的关键问题.
- 在减少射出分数 (HFrEF) 的高压中,运动增加了肌肉交感神经活动 (MSNA),与峰值氧气吸收 (V̇O2峰) 相反.
- 在保留射出分数 (HFpEF) 的HF中,这种同情激发反应的存在和意义仍然不清楚.
研究的目的:
- 研究与对照组相比,HFpEF患者在运动期间是否表现出增强的MSNA.
- 为了确定HFpEF中运动诱导的MSNA反应是否与运动能力有关 (V̇O2peak).
主要方法:
- 微神经图用于测量13名HFpEF患者的MSNA,17名并发症匹配对照 (CMCs) 和18名健康对照.
- 参与者进行了基线测量,对称和节奏握手练习以及单腿骑自行车.
- V̇O2peak使用开放电路螺旋计进行了评估.
主要成果:
- 与两组对照组相比,HFpEF患者的静止MSNA和V̇O2峰较高,V̇O2峰较低.
- 在手握运动期间,与对照组相比,HFpEF患者的MSNA升高.
- 虽然MSNA在健康对照中在循环中减少,在CMC中保持不变,但在HFpEF患者中显著增加. 在HFpEF中,在中度骑行期间MSNA的增加与V̇O2peak相反相关.
结论:
- 与对照组不同的是,患有HFpEF的患者在休息时表现出较高的MSNA,并在运动时表现出矛盾的同情刺激.
- 在HFpEF的动态循环过程中增强的同情反应与运动能力相反相关.
- 这些发现表明,神经性,血管收缩机制限制了HFpEF的运动能力.
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