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普雷沃特拉属植物调节结肠直肠癌免疫微环境,以协助抗PD-L1免疫疗法

Song Xu¹, Jianqiao Kong¹, Yang Dai¹

¹Department of General Surgery, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, China.

The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology

|December 6, 2024

概括

在结直肠癌 (CRC) 患者中,可能会增强抗PD-L1免疫疗法. 增加Prevotellaceae的丰富程度可以提高CRC治疗效率,并为未来的免疫治疗策略提供信息.

科学领域:

在瘤学瘤学.
微生物组研究微生物组研究
免疫治疗是一种免疫疗法.

背景情况:

大肠直肠癌 (CRC) 是全球领先的癌症.
免疫疗法,特别是抗PD-L1,在CRC治疗中表现有前途.
肠道微生物群的组成可能会影响抗PD-L1疗法的疗效.

研究的目的:

调查肠道细菌与CRC中的抗PD-L1治疗反应之间的联系.
探索Prevotellaceae和CRC中的免疫相关基因之间的关系.
通过小鼠模型验证Prevotellaceae丰度在抗PD-L1疗效中的作用.

主要方法:

生物信息学分析CRC患者的微生物群和免疫透.
16S rRNA测序用于小鼠的便Prevotellaceae丰富度.
流细胞计,西部斑点和qPCR用于评估瘤组织中的免疫细胞透和细胞因子水平 (IFN-γ,IL-2,PD-L1).

主要成果:

在CRC患者亚型之间观察到肠道微生物群社区均性的显著差异.
普雷沃特拉氏家族成员在特定的CRC亚型 (集群3) 中得到了丰富.
在体内实验证实,Prevotellaceae的丰富性支持抗PD-L1免疫疗法的有效性.

结论:

在结直肠癌中,Prevotellaceae促进了抗PD-L1治疗.
提高Prevotellaceae可能会增强CRC免疫疗法.
这些发现为开发改进的CRC免疫治疗策略提供了基础.

关键词:

这种植物属于Prevotellaceae.这是一种抗PD-L1的药物.结肠直肠癌是什么意思免疫微观环境免疫微环境免疫疗法免疫疗法

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