流通的FGF21在南亚人中较低,与患有2型糖尿病的欧洲人相比
Endocrine connections
|December 6, 2024
概括
与欧洲人相比,患有2型糖尿病 (T2DM) 的南亚人表现出明显的炎症特征,特别是纤维细胞生长因子21 (FGF21) 的水平明显较低. 需要进行进一步的研究,以了解低FGF21是否导致或导致该人群的T2DM.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 代谢疾病 代谢疾病
背景情况:
- 炎症是2型糖尿病 (T2DM) 发展的关键因素.
- 南亚人比欧洲人更容易患T2DM.
- 南亚2型糖尿病患者的炎症特征尚不清楚.
研究的目的:
- 研究南亚人和患有T2DM的欧洲人之间循环炎症相关蛋白质的差异.
- 在这些族群中识别与T2DM相关的特定蛋白质标记物.
主要方法:
- 三项随机对照试验的二次分析.
- 使用Olink目标炎症面板测量了73种与炎症相关的蛋白质的血水平.
- 使用ELISA对T2DM的荷兰南亚人和欧洲人进行量化血清纤维细胞生长因子21 (FGF21).
主要成果:
- 十二种与炎症相关的蛋白质在T2DM的南亚人和欧洲人之间显示出不同的水平.
- 纤维细胞生长因子21 (FGF21) 水平在南亚人中明显较低 (男性:-42.2%,女性:-58.5%).
- 这种FGF21的减少在南亚女性中尤为明显.
结论:
- 南亚和欧洲人与T2DM之间存在着与炎症相关的蛋白质特征的显著差异.
- 较低的血清FGF21水平是患有T2DM的南亚人的一个显著特征.
- 在南亚人中低FGF21和T2DM之间的因果关系需要进一步调查.
更多相关视频
07:22Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
Published on: March 7, 2025
197
08:47Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy
Published on: December 7, 2017
9.6K
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
2.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.2K
Diabetes: Symptoms, Diagnosis, and Complications
504
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
504
Diabetes Mellitus: Overview and Type I Subtype
2.4K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.4K
Pathophysiology of Diabetes
866
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
866
